my blog: 2012

Friday 27 April 2012

Nike Shoes

NIKE shoes are the twentieth century footwear that pronounced as NI-KEY which is a winged goddess of victory in Greek mythology who apperars beside os Zeus, ruler of Olympic, lifts the worlds greatest athletes to new levels of mastery and achievement. The nike swoosh symbol the spirit of the winged goddess. This is who inspired the most courageous at the dawn of the civilization.

The SWOOSH symbol is a graphic design. It is created by the Caroline Davidson in 1971. It represents the wing of the Greek Goddess NIKE.

Caroline Davidson was a student at Portland State University in advertising. She meet with Phil Knight while he was teaching accounting classes and started doing some freelance work for his company, Phil Knight asked Caroline to design a logo that could be placed on the side of shoe. She handed him the SWOOSH, in spring of 1972, the first shoe with the NIKESWOOSH was introduced.

The Nike athletic machine began as a small distributing outfit located in the trunk of Phil Knights car. From these rather inauspicious beginnings, Knights brainchild grew to become the shoe and athletic company that would come to define many aspects of popular culture and varieties of cool.

While getting his MBA at Stanford in the early60s, Knight took a class with Frank Shallenberger. The semester-long project was to devise a small business, including a marketing plan. They were attention to quality running shoes and the burgeoing opinion that high-quality/low cost products could be produced in Japan and shipped to the U.S.

For distribution, Knight found his market nice. Shallenberger thought the idea interesting, but certainly no business jackpot, nothing more became of Knighs project.

Cut to 1963, Phil Knight traveled to Japan on a world-tour, filled with the wanderlust of young men seeking a way to delay the invitable call of professional life, Knight scheduled an interview with a Japanese running shoe manufacturer.

Tiger--a subsidiary of the Onitsuka Company, presenting himself as the representative of an American distributor interested in selling Tiger shoes to American runners, Knight told the businessmen of his interest in their product.

By 1964, Knight had sold $8,000 worth of tigers and placed an order for more, Coach Bowerman and Knight worked together, but ended up hiring a full-time salesman, Jeff Johnson. After creating $1 million in sales and riding the wave of the success, Knight devised the Nike name and trademark Swoosh in 1971.

If Nike didnt start the fitness revolution, Knight says, "We were at least right there, and we sure rode it for one hell of a ride" . The 80s and 90s would yield greater and greater profits as Nike began to assume the appearance of athletic juggernaut, rather than the underdog of old. "Advertising Age" named Nike the 1996 Marketer of the Year, citing the "ubiquitous swoosh was more recognized and coveted by consumers than any other sports brand--arguably any brand".

In addition, Nike practice of top-level athletes promoting their products appeal to countless ages. These forces work powerfully upon the individual consumer, but one should not lose sight of the cultural context in which the individual moves.

Kisah seram yang aku alami dalam hidup.

kisah ini berlaku pada tahun 1998 ketika itu aku join satu kem di utara tanah air...pada mulanya aku rasa seronok dapat pergi menyertainya...dalam perjalanan kami semua bergembira seolah-olah pergi bercuti,kami bertolak pada sebelah pagi dengan menaiki bas yang di sewa khas..sampai di tempat yang di janjikan pada waktu malam...aku ingat lagi masa nak masuk kawasan tu kami perlu tempuh sebuah kawasan hutan...tiba-tiba salah seorang dari kami mengata..."mau nanti jumpa askar jepun tengah berkawat" itulah kata-kata dari salah seorang dari kami...yang lain tu tak berkata apa-apa...setalah kami turun dari bas kami pun di bawa masuk oleh renjer...yang herannya kami perlu tempuh satu gua...bayangkanlah kami terpaksa berjalan dalam gelap...salah seorang dari kami terpijak benda lembut yang...rasa-rasa aku ia adalah ular...setelah lama kami berjalan kami pun sampai di kem yang di sediakan...kami semua pun bersiaplah untuk tidur kerana...kami perlu bangun awal untuk berjoging...jam lebih kurang pukul 2 pagi waktu itu....entah kenapa ketika itu aku rasa sakit perut...semasa dalam perjalanan tadi renjer ada berkata kalau mahu kemana-mana hendaklah bawa kawan bersama...takut apa-apa terjadi,aku dengan tak tahan lagi aku lihat semua rakan aku tidur dengan nenyak sekali agaknya kepenatan sangat dalam perjalanan....jadi aku ambil keputusan untuk pergi sendirian sahaja...setelah aku selesai..aku keluar aku bertembung dengan rakan sibilik aku...aku pun tanya dia sakit perut ke dan member aku membalas ya...dan dia terus masuk ke bilik air,aku pun terus berjalan ke kem...semasa aku berjalan aku terpandang di dalam hutan...aku lihat pochong sdedang memandang tepat ke arah aku...aku dengan penatnya aku buat tak reti sahaja...lantak kaulah...dalam erti kata lain kepala tengah mai-mai (orang utara kata)aku pun terus menuju ke kem aku dan terus masuk tidur.keesokkan paginya aku tanya kawan aku yang aku jumpa malam tadi dia kata dia tak bangun pergi ke tandas...habis apa yang bertembung dengan aku malam tadi?.malam kedua kami semua berbual di luar hingga lewat malam kira-kira sampai pukul 1 pagi lepas tu kami semua masuk tidur.....pada pukul 3 pagi aku terjaga dan aku mendengar tentera sedang berkawat...bila aku mengintai dari jendela aku benar-benar melihat tentera jepun sedang berkawat di kawasan lapang...semenjak aku melihat perkara-perkara macam tu....aku jadi senyap dan tiada berkata apa-apa...ada member aku perasan yang aku jadi macam tu...mereka bertanya aku hanya jawap saja je.....malam ketiga pun macam tu...tapi kali ini kawan aku yang mengalaminya...selepas kejadian tu dia pun terus senyap je....dan malam ke empat ada juga kawan lain yang kena....dan bila hari terakhir baru renjer menceritakan yang tempat tu sebenarnya ialah kem askar jepun waktu dahulu...dan renjer berkata siapa yang dapat melihat nya adalah beruntung,bukan senang nak melihatnya....itu lah pengalaman aku semasa aku menyertai kem,dan sampai sekarang aku masih ingat peristiwa itu...itulah cerita yang aku nak share kat korang semua.

Thursday 26 April 2012

Sick Thalsssemia

Sickle Thalassemia ~ An Introduction

What is Thalassemia? Thalassemia is a genetic blood disorder, that triggers production of defective hemoglobin. Hemoglobin is the protein in red blood cells and responsible for carrying oxygen throughout the body. Instead these cells are destructed in groups, leading to anemia. Therea are different types of Thalassemia including alpha-thalassemia, beta-thalassemia, Cooley's anemia and Mediterranean anemia. While alpha and beta are more common.

What is Sickle Cell Anemia? Sickle cell anemia is another hereditary disease, where abnormal crescent shaped red blood cells are formed. There are times when both these conditions can overlap. Both these conditions cause anemia. There is yet another condition called Hemoglobin sickle-beta Thalassemia, colloquially referred to as Sickle Thalassemia. Also called as sickle beta thalassemia, or sickle cell-beta thalassemia, is a different form of sickle cell anemia. This disorder occurs when a kid gets two tweaked HBB genes, wherein one parent carried beta Thalassemia and other carried sickle cell anemia. It is believed to inherited owing to an autosomal recessive fashion, resulting from mutations in hemoglobin. This condition is more common with those from Mediterranean ancestry, like Greeks, Italians and Turks

Here, the severity of the condition can vary. Symptoms help in determining the severity. When mild, suppression degree of beta-chain synthesis is partial. In this case, red blood cells tend to contain 25% - 35% of the normal hemoglobin content. The treatment is generally easier, with the condition considered mild and often, does not need medical attention. On the other hand, severe form is when the beta-chain synthesis is suppressed in entirety.

The treatment is pretty serious, similar to homozygous sickle cell anemia. For severe form, patients may need blood transfusion at regular intervals. Also, antibiotics are suggested to avert pneumonia and other conditions. Pain killers are prescribed for reducing bouts of pain, though, they just offer relief for the time being. Being a disorder of the blood, spleen is affected as an aftermath. It is enlarged and even when taking treatment, it remains so for few years. Immune protection offered is also less and that's the most important cause for fatalities due to Thalassemia and related disorders.

Sickle beta +-Thalassemia is identified through a test called electrophoresis. This is done when a baby is 2 – 3 months of age. They take blood samples from the baby and send it to a laboratory. This will reveal if the kid has sickle cell trait, or if it has other complications. Based on this, the need for treatment will evaluate. Blood transfusion is one of the most common treatment for most enduring different types of Thalassemia. Other methods include Iron overload and Chelation therapy. The treatment is chosen based on the severity, type of problem and the patient's health.

Problems and symptoms of this condition can be similar to that of sickle cell anemia. Health problems due to this condition can include mild to severe anemia, constant pain in legs, arms, back and stomach. Also there is a risk of blood infections, gall stones, spleen enlargement and abrupt dropping of blood count.

Even now, research is ongoing to determine the cause, treatment and other related issues due to sickle cell Thalassemia.

Tuesday 24 April 2012

Thalassemia

What Is Thalassemia

T h a l a s s e m i a   is   b a s i c a l l y   th e   n a m e   for   a   s e t   o f   in h e r i t e d   g e n e t i c   di s o r d e r s   o f   t h e   bl o o d .   T o   b e
m o r e   pr e c i s e ,   t h a l a s s e m i a   is   a   di s o r d e r   in s i d e   t h e   re d   bl o o d   c e l l s   in   h u m a n   b o d y ,   s p e c i f i c a l l y
t h e   h e m o g l o b i n   m o l e c u l e .   T h a l a s s e m i a   is   a n   in h e r i t e d   g e n e t i c   di s o r d e r   or   g e n e t i c   di s e a s e ,
w h i c h   m e a n s   th a t   th e   di s e a s e   is   p a s s e d   o n   to   c h il d r e n   b y   p a r e n t s   thr o u g h   th e   g e n e s .
T h a l a s s e m i a   is   n o t   in f e c t i o u s   a t   all,   a n d   it   c a n   n o   w a y   b e   p a s s e d   t hr o u g h   bl o o d   tr a n s f u s i o n ,
c o n t a c t   wit h   a n o t h e r   p e r s o n ,   thr o u g h   bl o o d ,   air   or   fo o d .   T h a l a s s e m i a   p a t i e n t s   s h o u l d   n o t   b e
tre a t e d   a s   a n   o u t c a s t   d u e   t o   th e   m i s c o n c e p t i o n   o f   th e   di s e a s e   b e i n g   c o n t a g i o u s .
T h e r e   ar e   b a s i c a l l y   t w o   m a i n   ty p e s   o f   th a l a s s e m i a ,   a n d   th e y   ar e   al p h a   th a l a s s e m i a   a n d   b e t a
t h a l a s s e m i a .   B o t h   ty p e s   o f   th e   di s e a s e   in t e r f e r e s   wi t h   th e   n o r m a l   pr o d u c t i o n   o f   re d   bl o o d
c e l l s   b y   af f e c t i n g   th e   h e m o g l o b i n   m o l e c u l e s   in   th e   c e l l ,   w h i c h   ar e   a   k e y   f a c t o r   o f   t h e
d e v e l o p m e n t   a n d   fu n c t i o n   o f   h u m a n   re d   bl o o d   c e l l s .   T h e   pr o d u c t i o n   o f   a b n o r m a l   h e m o g l o b i n
ar e   k n o w n   a s   th e   S t r u c t u r a l   H e m o g l o b i n   V a r i a n t s ,   a n d   th e y   ar e   t h e   H e m o g l o b i n   S ,
H e m o g l o b i n   E ,   H e m o g l o b i n   C ,   H e m o g l o b i n   D   a n d   H e m o g l o b i n   L e p o r e .
T h e   dif f e r e n t   ty p e s   o f   S t r u c t u r a l   H e m o g l o b i n   V a r i a n t s   c o u l d   b e   v e r y   d a n g e r o u s ,   e s p e c i a l l y
w h e n   c o m b i n e d   wi t h   b e t a   th a l a s s e m i a ,   a s   it   pr o d u c e s   cr u c i a l   a n d   d a n g e r o u s   cli n i c a l l y
si g n i f i c a n t   bl o o d   di s o r d e r s   s u c h   a s   h e m o g l o b i n   E/   B e t a   th a l a s s e m i a ,   H e m o g l o b i n   L e p o r e /
B e t a   T h a l a s s e m i a   a n d   H e m o g l o b i n   S/   B e t a   T h a l a s s e m i a .   A s   d a n g e r o u s   a n d   f a t a l   a s   t h e y   ar e
b a c k   in   t h e   d a y s ,   t o d a y   th e   o u t l o o k   a n d   pr o g n o s i s   f or   p a t i e n t s   wi t h   t h a l a s s e m i a   is   lo o k i n g
b e t t e r   a s   tr e a t m e n t s   h a v e   i m p r o v e d .   P a t i e n t s   liv e   lo n g e r   a n d   le a d   q u a l i t y   liv e s ,   b u t   th e y   n e e d
t o   st a y   a d h e r e   to   t h e i r   tr e a t m e n t   pl a n s .   T h e   tre a t m e n t s   ar e   q u i t e   fre q u e n t ,   a n d   s u f f e r e r s   o f
s e v e r e   or   m o d e r a t e   th a l a s s e m i a   s h o u l d   stri c t l y   fo ll o w   th e i r   pr e s c r i b e d   tr e a t m e n t   pl a n s .
P a t i e n t s   wi t h   al p h a   th a l a s s e m i a   u s u a l l y   s h o w s   n o   si g n s   or   s y m p t o m s   a s   th e   di s o r d e r   is   m i n o r
t o   di s r u p t   t h e   fu n c t i o n   o f   th e   b o d y ' s   h e m o g l o b i n   in   re d   bl o o d   c e l l s .   H o w e v e r ,   th e y   ar e   sil e n t
c a rri e r s   o f   th e   g e n e .   P a t i e n t s   o f   th a l a s s e m i a   ar e   k n o w n   to   b e   s u s c e p t i b l e   t o   c a n c e r   b a s e d   o n
re c e n t   re s e a r c h   a s   to   h o w   th e i r   i m m u n e   h a s   d e c r e a s e d   a n d   t h e   la c k   o f   o x y g e n   d e l i v e r y
c a u s e s   c e l l s   to   di e .   T h i s   at tr a c t s   c a n c e r ,   a c c o r d i n g   to   re c e n t   st u d i e s ,   b u t   it   is   n o t   y e t
c o n f i r m e d .
T h a l a s s e m i a   p a t i e n t s ,   al p h a   or   b e t a   c o u l d   s u f f e r   fr o m   a n e m i a ,   a n d   it   c a u s e s   f a t i g u e   a n d
di z z i n e s s .   O t h e r s   si g n s   a n d   s y m p t o m s   for   th o s e   s u f f e r i n g   fr o m   th a l a s s e m i a   ar e   th e   lik e s   o f
sl o w   gr o w t h ,   b o n e   pr o b l e m s ,   e n l a r g e d   s p l e e n ,   p a l e   a p p e a r a n c e ,   p o o r   a p p e t i t e ,   d a r k   uri n e ,
a n d   ja u n d i c e   to   lis t   a   fe w   c o m m o n   o n e s .